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KMID : 0370219890330010064
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Yakhak Hoeji
1989 Volume.33 No. 1 p.64 ~ p.71
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Suicidal Inhibition Kinetics of MAO by Tranylcypromine Enantiomers
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Abstract
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Since time-dependent inactivation of MAO was found to be complete in a few minutes when high concentration ratios of tranylcypromine to MAO were used, a method to obtain kinetic parameters was sought suitable to the conditions in which concentrations of tranylcypromine analogs did not exceed that of MAO. For the purpose, kinetic equations were derived and the method applied to the kinetic studies of tranylcypromine enantiomers. It was found that (E)-( + )-2-phenylcyclopropylamine inhibited MAO by the mechanism following bimolecular reaction scheme with K; of 2.0 x 106M - lmin -1. Whereas, MAO-inhibitory pattern of the (- )-enantiomer was to be interpreted by suicide inhibition scheme and measured kin and. K´ were 0.457 min -1 and 5.4μM, respectively.
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KEYWORD
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